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High level production of itaconic acid at low pH by ...

High level production of itaconic acid at low pH by Ustilago maydis with fed-batch fermentation. Bioprocess Biosyst Eng. 2021 Apr;44 (4):749-758. doi: 10.1007/s00449-020-02483-6. Epub 2021 Jan 3.

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High level production of itaconic acid at low pH by ...

Jan 03, 2021  10%  Effect of pH on itaconic acid production under successive pulse-feeding. To observe the impact of cultivation at low pH on growth and itaconic acid production, cells were cultivated at pH 6, 5, and 4 and the fermentation is monitored both in its growth and itaconic production as well as corresponding rates (Fig. 5).

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High level production of itaconic acid at low pH by ...

itaconic acid production phase, carbon content increases from 42% to around 62%. Despite the gradual decrease in itaconic acid levels with decreasing pH (nearl y 50% decrease in itaconic acid

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Itaconic Acid - an overview ScienceDirect Topics

Conventionally, itaconic acid is produced by a batch fermentation process. During fermentation the pH value shifts towards lower values due to the production of the acid. To avoid product inhibition the pH is maintained at a high level by addition of sodium or ammonium hydroxide which form soluble salts with the produced itaconic acid.

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An Optimized Ustilago maydis for Itaconic Acid Production ...

Jul 01, 2020  An Optimized Ustilago maydis for Itaconic Acid Production at ... low pH, or nitrogen deficiency [23–25]. Filamentous growth causes issues such as high viscosity, reduced oxygen supply, and cell adherence to reactor walls [9]. This can be avoided

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An Optimized Ustilago maydis for Itaconic Acid Production ...

Dec 31, 2020  Furthermore, production of itaconic acid at low pH values is also paramount. Although U. maydis grows relatively poorly at low pH, the shaken cultures clearly indicate that the K14 strain is able to produce itaconic acid at pH levels below 4. A pH shift between growth and production may therefore enable low-pH production.

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Itaconic Acid - an overview ScienceDirect Topics

Conventionally, itaconic acid is produced by a batch fermentation process. During fermentation the pH value shifts towards lower values due to the production of the acid. To avoid product inhibition the pH is maintained at a high level by addition of sodium or ammonium hydroxide which form soluble salts with the produced itaconic acid.

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Influence of the pH on the itaconic acid production with ...

Sep 12, 2014  The effects of a pH shift in the itaconic acid production were quite different from a pH shift in the citric acid production using Aspergillus niger. Here, the increase of the pH during the cultivation results in a change in the product formation from citric acid (at low pH) to oxalic acid (high pH) (Cleland and Johnson 1956; Mischak et al. 1985).

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Production of Itaconic Acid in Microorganisms

Dec 21, 2020  In a study by van der Straat et al., the authors attempted to produce itaconic acid in A. niger; this was chosen as it is capable of producing high levels of citric acid (200g/L), and the pathways ...

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Metabolic specialization in itaconic acid production: a ...

Nov 02, 2019  High level production of itaconic acid at low pH by Ustilago maydis with fed-batch fermentation. Demir HT, Bezirci E, Becker J, Tehrani HH, Nikerel E, Wierck N, Türker M. Bioprocess Biosyst Eng, 44(4):749-758, 03 Jan 2021 Cited by: 0 articles PMID: 33392747

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Biochemistry of microbial itaconic acid production - Frontiers

Feb 14, 2013  Itaconic acid is an unsaturated dicarbonic acid which has a high potential as a biochemical building block, because it can be used as a monomer for the production of a plethora of products including resins, plastics, paints, and synthetic fibers. Some Aspergillus species, like A. itaconicus and A. terreus, show the ability to synthesize this organic acid and A. terreus can secrete

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Biotechnological production of itaconic acid Request PDF

Despite the gradual decrease in itaconic acid levels with decreasing pH (nearly 50% decrease in itaconic acid at pH 3.5, compared to pH 6), significant itaconate production is still observed at pH ...

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Production of itaconic acid from alkali pretreated lignin ...

Apr 15, 2021  Itaconic acid is an unsaturated dicarboxylic acid derived from cis-aconitate in the TCA cycle, with industrial uses including as an acrylate alternative and for the production of polymers. 13 ...

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Biotechnological production of itaconic acid—things you ...

Mar 13, 2018  Itaconic acid is one of the basic chemicals for the polymer industry, which can be produced on the basis of renewable raw materials. Since the middle of the twentieth century, itaconic acid has been produced industrially using the filamentous fungus Aspergillus terreus.But the demand for the organic acid is low due to the high production costs compared to alternative petrochemical

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Systems‐level approaches for understanding and engineering ...

Jun 15, 2021  The production of succinic acid (SA) in Y. lipolytica has also undergone metabolic engineering efforts (Abdel-Mawgoud et al., 2018). Unlike SA-producing bacteria, which are among the most successful producers to date, Y. lipolytica can tolerate low pH and thrives under acidic conditions.

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Biotechnological production of itaconic acid, Applied ...

Aug 27, 2001  Itaconic acid (IA) is an unsaturated dicarbonic organic acid. It can easily be incorporated into polymers and may serve as a substitute for petrochemical-based acrylic or methacrylic acid. It is used at 1–5% as a comonomer in resins and also in the manufacture of synthetic fibres, in coatings, adhesives, thickeners and binders. The favoured production process is fermentation of

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Itaconic acid - SCBT

Itaconic acid sc-250207 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Itaconic acid STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware

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Metabolic responses of Aspergillus terreus under low ...

Mar 07, 2018  Dissolved oxygen and pH regulated metabolite production in the 2-phase fermentation. Table 1 represents the fermentation kinetics data of A. terreus NRRL1960 during the second phase in the two-phase fermentation cultivated at low DO levels (10, 15, and 20%). Itaconic acid and fumaric acid were observed in the fermentation broth during the second phase in all of the conditions studied.

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A systems biology approach for the identification of ...

Dec 04, 2013  Itaconic acid as a building block chemical is used in industry [1–4].Currently, the most commonly used production host for this compound is Aspergillus terreus.However, its market price is relatively high which restricts its broader industrial application [].Therefore, a new production host – Aspergillus niger was introduced for producing itaconic acid towards more economical levels [].

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Process development of itaconic acid production by a ...

Feb 25, 2017  High level production of itaconic acid at low pH by Ustilago maydis with fed-batch fermentation. Demir HT, Bezirci E, Becker J, Tehrani HH, Nikerel E, Wierck N, Türker M. Bioprocess Biosyst Eng, 44(4):749-758, 03 Jan 2021 Cited by: 0 articles PMID: 33392747

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Genetic and biochemical insights into the itaconate ...

Oct 14, 2016  High level production of itaconic acid at low pH by Ustilago maydis with fed-batch fermentation. Demir HT, Bezirci E, Becker J, Tehrani HH, Nikerel E, Wierck N, Türker M. Bioprocess Biosyst Eng, 44(4):749-758, 03 Jan 2021 Cited by: 0 articles PMID: 33392747

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Biotechnological production of itaconic acid—things you ...

Mar 13, 2018  Itaconic acid is one of the basic chemicals for the polymer industry, which can be produced on the basis of renewable raw materials. Since the middle of the twentieth century, itaconic acid has been produced industrially using the filamentous fungus Aspergillus terreus.But the demand for the organic acid is low due to the high production costs compared to alternative petrochemical

Get Price

Publications - RWTH AACHEN UNIVERSITY Institute of Applied ...

High level production of itaconic acid at low pH by Ustilago maydis with fed-batch fermentation Bioprocess and biosystems engineering 44, 749–758 (2021) Demir, Hatice Taşpınar

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Production of itaconic acid from alkali pretreated lignin ...

Apr 15, 2021  Itaconic acid is an unsaturated dicarboxylic acid derived from cis-aconitate in the TCA cycle, with industrial uses including as an acrylate alternative and for the production of polymers. 13 ...

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Itaconic acid - SCBT

Itaconic acid sc-250207 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Itaconic acid STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware

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RESEARCH ARTICLE Open Access A systems biology approach ...

highly related to itaconic acid production would be influenced by these environmental factors. The batch cul-tivations were carried out with various carbon sources, different levels of trace elements (e.g. Mn2+), pH and dis-solved oxygen supplies, which resulted in different levels of itaconic acid production. Among them, pH had a strong

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Biotechnological production of itaconic acid, Applied ...

Aug 27, 2001  Itaconic acid (IA) is an unsaturated dicarbonic organic acid. It can easily be incorporated into polymers and may serve as a substitute for petrochemical-based acrylic or methacrylic acid. It is used at 1–5% as a comonomer in resins and also in the manufacture of synthetic fibres, in coatings, adhesives, thickeners and binders. The favoured production process is fermentation of

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Method for the production of itaconic acid using ...

Yield is defined as Yield (%)=itaconic acid production (g/g of medium)/initial medium total sugar content (g/g of medium)×100%. 2) Medium support: The use of unpeeled or peeled sugarcane pressmud as support enables high levels of oxygen to be in and moving through the system easily at all times.

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Organic acid toxicity, tolerance, and production in ...

Aug 25, 2005  The maximum yield in succinic acid production was approximately 50 g/L in pH controlled cultures. However, similar to lactic acid studies, succinic acid production was significantly repressed when pH was not kept at neutral levels. A final example of metabolic engineering organic acid production in E. coli was reported by Cargill in 2001 .

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A systems biology approach for the identification of ...

Dec 04, 2013  Itaconic acid as a building block chemical is used in industry [1–4].Currently, the most commonly used production host for this compound is Aspergillus terreus.However, its market price is relatively high which restricts its broader industrial application [].Therefore, a new production host – Aspergillus niger was introduced for producing itaconic acid towards more economical levels [].

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ORIGINAL ARTICLE Gluconic acid production by Aspergillus ...

Another carboxylic acid, itaconic acid (methylenesucci-nic acid), is biosynthesized by A. terreus at low pH, worldwide production exceeding 8Æ0 104 tons per year (Okabe et al. 2009). The same organism under different fermentation conditions and with a higher operating pH elaborates secondary metabolites, including lovastatin (Bi-

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Metabolic responses of Aspergillus terreus under low ...

Mar 07, 2018  Dissolved oxygen and pH regulated metabolite production in the 2-phase fermentation. Table 1 represents the fermentation kinetics data of A. terreus NRRL1960 during the second phase in the two-phase fermentation cultivated at low DO levels (10, 15, and 20%). Itaconic acid and fumaric acid were observed in the fermentation broth during the second phase in all of the conditions studied.

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Development of Integrated Production of Polyitaconic Acid ...

Progress 09/01/09 to 02/29/12 Outputs OUTPUTS: The main goal of this project was to develop an integrated process for producing polyitaconic acid through the fermentation of a biomass-based sugar feedstock. Currently, there is no commercial source of itaconic acid in the United States. Itaconix Corporation, the prime for this award, is a company which requires itaconic acid as the feedstock ...

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